
How much does the leptospirosis vaccine cost?
How much does the leptospirosis vaccine cost?
$25 – $50 average cost per dose
$50 – $100 average total cost (2 doses)

Average leptospirosis vaccine cost
A leptospirosis vaccine for dogs costs $25 to $50 per dose or $50 to $100 total for both doses. Lepto vaccine costs depend on the location and whether the vaccine is a standalone shot or part of a combination vaccine. Some clinics charge additional fees for the required veterinary examination prior to vaccination.
Number of shots | Average total cost |
---|---|
One dose | $25 – $50 |
Two doses | $50 – $100 |
What is leptospirosis in dogs?
Leptospirosis, or lepto, is a serious bacterial disease caused by Leptospira bacteria. It is a zoonotic infection, meaning it can affect both animals and humans worldwide. In dogs, leptospirosis can lead to severe illness, including kidney and liver failure, and can be fatal if not treated promptly.
Dogs can catch leptospirosis through contact with water, soil, or food contaminated by the urine of infected animals, most commonly rodents and wildlife. Some symptoms of leptospirosis include:
Fever
Lethargy
Diarrhea
Vomiting
Lack of appetite
Muscle pain and stiffness
Leptospirosis vaccine price factors
Several other factors can influence the cost of lepto vaccination:
Exam fees: Most clinics require a physical exam before vaccination. If the clinic charges a separate fee, vet visits cost $40 to $80 on average.
Combo vaccines: The leptospirosis vaccine is often available as part of a combination shot like DHLPP, which can be more cost-effective than purchasing vaccines individually.
Geographic location: Prices can vary by city and region, with urban areas sometimes charging slightly more due to higher operational costs.
Pet insurance: If you have pet insurance, it may cover vaccinations. Pet insurance costs and coverage vary by plan, so always review your policy to confirm.
Payment options: Some vet clinics offer payment plans or lower rates for upfront cash payments.
Leptospirosis vaccine side effects
The leptospirosis vaccine, like all vaccines, can cause side effects in some dogs. Most reactions are mild and temporary, but rare serious reactions can occur.
Small-breed and young adult dogs may be at higher risk for vaccine reactions, particularly if they receive multiple vaccines in one visit. Certain breeds, such as Dachshunds and West Highland White Terriers, have shown a slightly increased risk of hypersensitivity reactions.
Side effect severity | Examples | Frequency |
---|---|---|
Mild |
|
Common |
Moderate |
|
Less common |
Severe |
|
Rare |
Lepto vs. other vaccines
Dog vaccinations cost $75 to $400+ for a puppy's first year and $35 to $365+ per year afterward. The core vaccines in the schedule include DHPP/DAPP (distemper, hepatitis/adenovirus, parainfluenza, parvovirus) and the rabies shot. Many vets offer a combination vaccine called DHLPP that includes DHPP and lepto.
On its own, the rabies vaccine for dogs costs $15 to $30 for a puppy's first year and $25 to $60 for an adult dog every 1 to 3 years.
Leptospirosis vaccine FAQs
How do dogs get leptospirosis?
Dogs contract leptospirosis by coming into contact with the urine of infected animals or with water, soil, food, or bedding contaminated by that urine. The bacteria enter the body through the mouth, nose, eyes, or broken skin, especially after exposure to puddles or mud.
Can leptospirosis be prevented?
Vaccination is the most effective way to prevent leptospirosis in dogs because it protects against several common strains of the bacteria. Limiting your dog's exposure to potentially contaminated water sources and discouraging contact with wild animals can further reduce risk, but vaccination remains the primary preventive measure.
Can dogs die from the leptospirosis vaccine?
Death from the leptospirosis vaccine is extremely rare. Most dogs experience only mild, temporary side effects, such as soreness or lethargy. Severe allergic reactions can occur but are uncommon. The benefits of vaccination, especially for dogs at risk, far outweigh the risks for most pets.
How common is leptospirosis in dogs?
Leptospirosis is more common in warm, wet climates and after periods of heavy rainfall or flooding. All dogs are at risk, regardless of age or breed, but those exposed to wildlife, farm animals, or contaminated water have a higher likelihood of infection. Regional hotspots include the midwestern, eastern, and southwestern United States.
Can cats get leptospirosis?
Cats can catch leptospirosis, but this rarely happens. While many mammals are susceptible to the bacteria, dogs contract lepto much more often than cats, and clinical illness in cats is uncommon.
How is leptospirosis transmitted?
Leptospirosis spreads primarily through the urine of infected animals, especially rodents and wildlife. Dogs become infected when urine or contaminated water, soil, or food contacts their mucous membranes or broken skin. The bacteria can survive in moist environments for weeks to months, making transmission possible in rural and urban settings.

Questions to ask your vet
Ask your veterinarian these to make informed decisions about your dog's vaccination:
Which brand or formulation of the leptospirosis vaccine do you use, and why do you recommend it for my dog?
How effective is this vaccine, and which strains of leptospirosis does it protect against?
What potential side effects or risks should I expect from this vaccine for my dog's breed or age?
How have you evaluated my dog's risk of exposure to leptospirosis based on our local area and my dog's lifestyle?
How common is leptospirosis in our region, and have you seen recent outbreaks nearby?
How often do you recommend booster shots after the initial vaccination series?
Can you administer the leptospirosis vaccine with other vaccines during the same visit, or will you give it separately?
What signs should I watch for after vaccination?
When should I contact you if I notice a reaction?
Are there any reasons you would advise against giving my dog the leptospirosis vaccine?
How do the latest vaccines compare to older versions in terms of safety and effectiveness?
Will the vaccine fully prevent leptospirosis, or should I take additional precautions to protect my dog?